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Schematic illustration of (a) aPD1 and caged restriction enzyme loaded DNA nanococoon (DNC), (b) In vivo tumor immunotherapy after primary tumor resection, local injection, and treatment of DNC-based delivery system and (c) Activation of DCs by CpG which in turn activates T cell response with aPD1 for PD 1 blockade. Reproduced with permission from [127]. Copyright 2016, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
