Table 2.
Top 20 drugs and their toxicities, ranked by point-of-departure.
| Substance | Rank (PoD) | Tox@PoD | Rank (GI) | Tox@GI | Rank (AUC) |
|---|---|---|---|---|---|
| Actinomycin D | 1 | 0.636 | 3 | 0.596 | 6 |
| Dinaciclib | 2 | 0.641 | 4 | 0.586 | 8 |
| Ganetespib | 3 | 0.600 | 6 | 0.566 | 3 |
| Staurosporine | 4 | 0.654 | 5 | 0.472 | 2 |
| MLN9708 | 5 | inf | 8 | inf | 4 |
| Carfilzomib | 6 | 0.930 | 9 | 0.930 | 5 |
| Homoharringtonine | 7 | 0.696 | 10 | 0.659 | 9 |
| PF-04691502 | 8 | 0.329 | 11 | 0.345 | 14 |
| BAY 80-6946 | 9 | inf | 12 | inf | 13 |
| Obatoclax | 10 | 0.434 | 14 | 0.534 | 11 |
| Panobinostat | 11 | 0.639 | 15 | 0.658 | 16 |
| Romidepsin | 12 | 0.005 | 7 | 0.000 | 7 |
| Auranofin | 13 | inf | 16 | inf | 15 |
| 17-AAG | 14 | inf | 17 | inf | 17 |
| Rigosertib sodium | 15 | 0.477 | 24 | 0.477 | 25 |
| Idarubicin hydrochloride | 16 | 0.790 | 18 | 0.834 | 19 |
| Daunorubicin hydrochloride | 17 | 0.675 | 20 | 0.710 | 20 |
| Vinflunine tartrate | 18 | 0.404 | 97 | inf | 63 |
| Doxorubicin hydrochloride | 19 | 0.735 | 21 | 0.736 | 23 |
| Ponatinib | 20 | 0.854 | 23 | 0.894 | 21 |