Figure 1.

CD37 function in B cell. CD37 molecule is involved in activatory (PI3Kδ/p-Akt/p-GSK3/β-catenin) and inhibitory (SHP1/p-Akt/Foxo3; SOCS3/Jak) signaling pathways. ITAM: immune tyrosine-based activation motif; ITIM: immune tyrosine-based inhibitory motif; IL-6R: Interleukin 6 Receptor; SOCS3: suppressor of cytokine signaling 3; Jak: Janus Kinase; STAT3: Signal Transducer and Activator of Transcription 3; PI3K: phosphatidylinositol 3-kinase; p-Akt: phospho-Akt; mTOR- mammalian target of rapamycin; SHP-1: Src homology region 2 domain-containing phosphatase-1; FOXO3: Forkhead box O3; p-GSK3: phospho-glycogen synthase kinase 3; TCF/LEF: T cell factor/lymphoid enhancer factor.