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. 2020 Dec 15;9(12):1282. doi: 10.3390/antiox9121282

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Miraculin interacts with sweet taste receptors TAS1R2 and TAS1R3 in the oral cavity and at the gastrointestinal (GI) level. The intracellular signaling pathways stimulate the taste receptors downstream under acidic conditions. Miraculin may contribute to the regulation of GI motility and the secretion of enterohormones (leptin, ghrelin, insulin, GLP-1, and endocannabinoids). The described SNPs in TAS1R affect taste sensitivity, sugar intake, and their interactions with body mass index (BMI). (The figure has been created by BioRender.com).