Table 4.
Validated variants in ABC transporters significantly associating with the response of patients to the neoadjuvant cytotoxic therapy.
| Gene | SNP ID | Genotype | Good Response 1 | Poor Response 1 | χ-Square | p-Value |
|---|---|---|---|---|---|---|
| ABCA4 | rs2275032 | AA | 75 | 33 | 6.33 | 0.042 |
| CA | 48 | 7 | ||||
| CC | 4 | 1 | ||||
| ABCA9 | rs11871944 | CC | 48 | 24 | 6.76 | 0.034 |
| CT | 61 | 14 | ||||
| TT | 18 | 2 | ||||
| ABCA12 | rs71428357 | CC | 103 | 41 | 8.32 | 0.004 |
| CT + TT | 22 | 0 | ||||
| ABCB5 | rs3210441 | GG | 42 | 11 | 6.22 | 0.045 |
| GA | 62 | 28 | ||||
| AA | 23 | 2 | ||||
| ABCC5 | rs4148579 | CC | 43 | 6 | 8.55 | 0.014 |
| CT | 68 | 24 | ||||
| TT | 15 | 11 | ||||
| ABCC8 | rs739689 | AA | 55 | 11 | 6.81 | 0.033 |
| GA | 60 | 21 | ||||
| GG | 11 | 9 | ||||
| ABCC11 | rs17822931 | CC | 89 | 37 | 6.42 | 0.011 |
| CT + TT | 37 | 4 | ||||
| ABCD4 | rs2301347 | CC | 53 | 9 | 8.59 | 0.014 |
| CA | 60 | 21 | ||||
| AA | 14 | 11 | ||||
| ABCD4 | rs2301346 | TT | 73 | 15 | 7.28 | 0.026 |
| CT | 45 | 20 | ||||
| CC | 7 | 6 |
1 Numbers of patients with specified genotypes divided by response to the neoadjuvant treatment.