Figure 5.

Example of the complex chromosome aberrations of a SF3B1-mutated tumour of a 38 year old female. Shown is (a) metaphase spread with DAPI staining, (b) spectral karyotyping in which each chromosome has a specific color, (c) red chromosome 8 paint and green telomeric 6q probe and (d) spectral karyotype showing exchanges between different chromosomes. For instance, part of chr6 (red) is attached to the bottom part (q-arm) of chromosome 5 (orange). The upper arm (p-arm) of chromosome 7 has material of chromosome 11 (blue) and 8 (green). Full karyotype in Naus et al. [53].