Figure 3.

The structural features of the Orai1 channel. (a) The scheme shows the full-length human Orai1 channel with highlighted regions and residues that are essential for the Orai1 function. (b) The cartoon of one Orai1 subunit with four TM segments along with N- and C- terminal helices are depicted in distinct colors (same as applied within (a)). The separated circles of the respective Orai1 subunit regions display the most prominent mutations that are known to lead to either loss of function (red stop sign) or gain of function (blue circle) of the Orai1 channel. (c) The scheme of Orai1 subunit with marked residues represent positions linked to diverse diseases or cancer.