Figure 4.

Closed versus open dOrai structure and pore architecture. (a–c) The top and corresponding side view of the dOrai channel crystal structure of the closed state (a), open state (P288L) (PDB ID: 6AKI) (b) and cryo EM structure of the open state (P288L) (c) are depicted. (d) The pore region of the closed state (light-colored TM1 helices) and the corresponding pore profiles are depicted in pink. The structure is overlaid by an open pore structure of dOrai P288L (dark blue and purple TM1 helices) while its pore architecture is depicted in dark purple color.