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Potential scenarios of SK3-Orai1 interplay. The direct interaction and tight co-regulation between SK3 and Orai1 and potentially STIM1 (right panel). The indirect interaction between SK3- and Orai1-mediated through probable modulators such as SPCA2, SigmaR1, Caveolin-1, TRP family or members of cAMP-PKA pathway (left panel) in addition to the possible role of STIM1.
