1-EBIO	1-Ethylbenzimidazolinone
2-APB	2-aminoethoxydiphenyl borate
4-AP	4-aminopyridine
Å	Angstrom (unit of length equal to 10−10 m)
aa	Amino acid
AC8	Adenylyl cyclase 8
Akt	Known as protein kinase B or PKB
ARC	Arachidonic acid (AA)-activated channels
ATP	Adenosine triphosphate
ANSGA	4-Point mutation in hinge region aa position 261–265
ATPase	Adenosine triphosphatase
BK	Large conductance, Ca2+-activated potassium channels
BTP2	[N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide]
Ca2+	Calcium ion
CAD	Ca2+ release-activated Ca2+-activating domain
CaM	Calmodulin
cAMP	Cyclic adenosine monophosphate
CAR	Ca2+ accumulating region
CaV1	Caveolin-1
CC	Coiled-coil
Ccb9	Coiled-coil domain containing region b9
cEF	Canonical EF hand
CRAC	Ca2+ release-activated Ca2+
CRACR2A	Calcium release activated channel regulator 2A
CRISPR/Cas9	Clustered regularly interspaced short palindromic repeats/Cas
Cs+	Cesium ion
Cyppa	N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4 pyrimidinamine
∆	Represents deletion mutants
dOrai	Drosophila melanogaster Orai
DVF	Divalent-free
EDA	Ectodermal dysplasia
EGF	Epidermal growth factor
EGTA	Ethylene glycol tetraacetic acid
ER	Endoplasmic reticulum
ERα	Estrogen receptor-α
ERK1/2	Extracellular-signal-regulated kinases 1 and 2
ETON	Extended transmembrane Orai1 N-terminal
FCDI	Fast calcium-dependent inactivation
FRAP	Fluorescence recovery after photobleaching
FRET	Fluorescence resonance energy transfer
GBM	Glioblastoma multiforme cells
GoF	Gain of function
GSK	GlaxoSmithKline compounds
HEK	Human embryonic kidney
I/V	Current voltage relationship
ICa2+	CRAC current
INa+	Sodium current in sodium divalent free solution
ID	Inhibitory domain
IH	Inhibitory helix
IK	Intermediate Ca2+-activated K+ channels
IP3	Inositol-triphosphate
IP3R	Inositol-triphosphate receptor
K+	Potassium ion
KCa	Ca2+-activated K+ channels
Kir	Inward-rectifier potassium channels
L1-L3	Loop 1–3 (of Orai channels)
L-type	Long-lasting calcium channel
LGC	Ligand gated calcium channels
LoF	Loss of function
MCU	Mitochondrial Ca2+ uniporter
MD simulations	Molecular dynamics simulations
Na+-DVF	Sodium divalent free
nEF	Non-canonical EF hand
NFAT	Nuclear factor of activated T cells
nAChR	Nicotinic acetylcholine receptors
NS309	3-Oxime-6,7-dichloro-1H-indole-2,3-dione
NS3893	N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride
NMR	Nuclear magnetic resonance
OASF	Orai-activating small fragment
Orai 1–3	Orai proteins (also as O1–3)
P/S	Proline, serine
P-Akt	Phosphorylated known as protein kinase B or PKB
PI3K	Phosphoinositide 3-kinases
PIP2	Phosphatidylinositol 4,5-bisphosphate
PKA	Protein kinase A
PKC	Protein kinase C
PM	Plasma membrane
PMCA	Plasma membrane Ca2+ ATPase
Ref	References
S	Signal peptide
SAM	sterile α-motif
SARAF	Store-operated calcium entry associated regulatory factor
SCDI	Slow calcium-dependent inactivation
SCID	Severe combined immune deficiency
SigmaR1	Sigma non-Opioid intracellular receptor 1
SK channels	Small-conductance Ca(2+)-activated K(+) channels
SKA-111	5-Methylnaphtho[1¨C-d]thiazol-2-amine
SKA-121	5-Methylnaphth[2,1-d]oxazol-2-amine
SOAP	STIM-Orai association pocket
SOAR	STIM-Orai activating region
SOC	Store operated channel
SOCE	Store-operated calcium entry
SPCA2	Secretory pathway Ca2+-ATPase
STIM	Stromal interaction molecule
STRMK	Stormorken syndrome
Synta66	4-Pyridinecarboxamide
TAM	Tubular Aggregate Myopathy
TM	Transmembrane helices
TRP	Transient receptor potential ion channel (C-canonical, M-melastatin, V-vallinoid)
VGCC	Voltage gated calcium channels