Table 3.
SK channel modulators. This table summarizes the most common SK channel modulators together with their empirical formula, the function of interest and some additional information.
| Name | Empirical Formula | Function of Interest | Additional Information | References |
|---|---|---|---|---|
| 1-EBIO | C9H10N2O | Activates: SK1, SK2, SK3, SK4 | - | [313,318,323] |
| NS309 | C8H4Cl2N2O2 | Activates: SK1, SK3, SK4 | Blocks: L-type channel | [314,316,318] |
| Riluzole | C8H5F3N2OS | Activates: SK1, SK2, SK3, SK4 | Activates: TRPC5 channel | [313,324] |
| CyPPA | C16H23N5 | Activates: SK2, SK3 | Blocks: TRPM7 | [314,318,325] |
| SKA-111 | C12H10N2S | Activates: SK4 | - | [326] |
| SKA-121 | C12H10N2O | Activates: SK4 | - | [326] |
| ICAGEN | C13H10N4S | Blocks: SK1, SK2, SK3 | - | [315] |
| NS8593 | C17H18ClN3 | Blocks: SK1, SK2, SK3 | Blocks: TRPM7 | [315,318,327] |
| BMB | C21H20BrNO6 | Blocks: SK3 | Blocks: gamma-aminobutyric acid (GABA)-gated Cl- channels | [314] |
| Apamin | C79H131N31O24S4 | Blocks: SK1, SK2, SK3 | - | [312,328] |
| TRAM34 | C22H17ClN2 | Blocks: SK4 | - | [318,329] |
| 4-AP | C5H6N2 | Blocks: SK3 | Blocks: Voltage gated potassium channels | [317] |
| RA-2 | C22H16F2O6 | Blocks: SK1, SK2, SK3, SK4 | - | [330] |
| Alkyl-ether-lipids | - | Blocks: SK3 | - | [38,317] |