Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Imidazopyridazine inhibitors of PfCDPK1.
| Compound | R1 | R2 | PfCDPK1 IC50 (nM) | Pf3D7 IC50 (nM) | In Vivo Parasitemia Reduction 1 |
|---|---|---|---|---|---|
| 5 |
|
|
13 | 400 | 46 |
| 6 |
|
|
70 | 103 | - |
| 7 |
|
|
<10 | 12 | 4% |
| 8 |
|
|
12 | 80 | 51% |
1 Four-day Peter’s test [27] at an oral dose of 50 mg/kg/day.
