Table 3.

ADMET parameters of compound 13 and 14 [37].

	In Vitro		In Vivo
Compound	Solubility (µM) in Buffer pH 6.5	t1/2 (min) Human Liver Microsome	AUC 1 (µM·min) at 10 mg/kg per os	AUC 1 (µM·min) at 10 mg/kg Intraperitoneal	t1/2 (h) at 100 mg/kg per os
13	47	-	57	317	-
14	82	>60	430	863	13.5

¹ AUC = Area Under Curve.