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Pantothenate and pantothenate analog inhibitors of PfPanK.
| Compound | P. falciparum IC50 (µM) 1,2 | Pantothenate Phosphorylation Inhibition % | PfPanK IC50 |
|---|---|---|---|
|
- | - | - |
|
76 | >85% (at 1 mM) | - |
|
36 | - | 14 µM |
|
13 | >60% (at 10 µM) | 140 nM |
|
0.03 | - | - |
1Pf3D7 strain except for 39, where the value shown is on PfW2 strain. 2 Pantothenate concentration in growth medium was 1 µM except for 39, where it was 1.14 µM.
