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. 2020 Dec 15;25(24):5949. doi: 10.3390/molecules25245949

Table 7.

Thieno[2,3-b]pyridine inhibitors of PfGSK3.

graphic file with name molecules-25-05949-i012.jpg

Compound R % Inhibition PfNF54LUC at 3 µM PfGSK3 IC50 (µM) HsGSK3 IC50 (µM) PfNF54LUC IC50 (µM) CC50 (HEK293, µM)
48 graphic file with name molecules-25-05949-i028.jpg n.d. 1 0.24 9.08 5.5 35.2
49 graphic file with name molecules-25-05949-i029.jpg 99.9 0.72 40.2 1.2 5.56
(+)-50 graphic file with name molecules-25-05949-i030.jpg 73.0 n.d. n.d. 1.1 n.d.
(−)-50 graphic file with name molecules-25-05949-i031.jpg −24.4 n.d. n.d. n.d. n.d.

1 n.d. = not determined