Table 8.
Isobenzothiazolinones and ebselen as inhibitors of PfHK.
| Compound | X | R1 | R2 | PfHK IC50 (nM) | Pf3D7 EC50 (µM) |
|---|---|---|---|---|---|
| 51 | S | F | Cl | 160 | 0.62 |
| 52 | S | H | Cl | 270 | 1.1 |
| 53 | S | H | H | 230 | 5.2 |
| 54 | S | H | H | 10 | 6.8 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.