Table 1.
List of liposomal drug products for injection clinically approved by European Medicines Agency (EMA) and Food and Drug Administration (FDA).
| Drug | Product Name | Route of Administration | Lipid Composition (Molar Ratio 1) | Treatment | Ref. |
|---|---|---|---|---|---|
| Amphotericin B | Abelcet | Intravenous | DMPC, DMPG (7:3) | Systemic fungal infections | [16] |
| Ambisome | Intravenous | HSPC, DSPG, cholesterol (2:0.8:0.4) | Systemic fungal infections | [17] | |
| Bupivacaine | Exparel | Supraperiosteal Injection | DEPC, DPPG, cholesterol, tricaprylin | Postsurgical local analgesia | [18] |
| Nocita | Supraperiosteal Injection | DEPC, DPPG, cholesterol, tricaprylin | Postsurgical local analgesia (for dogs only) | [19] | |
| Cytarabine | Depocyt | Spinal | DOPC, DPPG, cholesterol, triolein (7:1:11:1) | Lymphomatous meningitis | [20] |
| Daunorubicin | DaunoXome | Intravenous | DSPC, cholesterol (2:1) | Kaposi’s sarcoma | [21] |
| Doxorubicin | Doxil/Caelyx 2 | Intravenous | HSPC, cholesterol, DSPE-PEG (2000) (56:39:5) | Kaposi’s sarcoma | [22] |
| Lipodox | Intravenous | DSPC, cholesterol, DSPE-PEG (2000) (56:39:5) | Kaposi’s sarcoma, ovarian/breast cancer | [23] | |
| Myocet liposomal 3 | Intravenous | EPC, cholesterol (55:45) | Metastatic breast cancer | [24] | |
| Inactivated hepatitis A virus | Epaxal | Intramuscular | DOPC, DOPE (75:25) | Hepatitis A | [25] |
| Inactivated hemagglutinin of influenza virus strains A and B | Inflexal V | Intramuscular | DOPC, DOPE (75:25) | Influenza | [26] |
| Irinotecan | Onivyde | Intravenous | DSPC, MPEG-2000-DSPE | metastatic adenocarcinoma of the pancreas | [27] |
| Mifamurtide | Mepact 2 | Intravenous | POPC, DOPS (7:3) | High-grade non-metastatic osteosarcoma | [28] |
| Morphine sulfate | DepoDur | Epidural | DOPC, DPPG, cholesterol, triolein (7:1:11:1) | Pain management | [29] |
| Verteporfin | Visudyne | Intravenous | DMPC, EPG (5:3) | Age-related macular degeneration, pathologic myopia, ocular histoplasmosis | [30] |
| Vincristine sulfate | Marqibo | Intravenous | Sphingomyelin, cholesterol (6:4) | Acute lymphoblastic leukaemia | [31] |
HSPC—hydrogenated soya bean phosphatidylcholine; DSPG—1,2-distearoyl-sn-glycero-3-phosphoglycerol; DEPC—1,2-dierucoyl-sn-glycero-3-phosphocholine; DSPE-PEG(2000)—1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]; EPC—egg phosphatidylcholine; MPEG-2000-DSPE—1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000]; DOPS—1,2-dioleoyl-sn-glycero-3-phospho-L-serine; EPG—egg phosphatidylglycerol. 1 If available. 2 Outside the United States, Doxil is known as Caelyx. 3 These formulations are only approved by EMA and not by FDA.