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. 2020 Dec 16;21(24):9575. doi: 10.3390/ijms21249575

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of Akt and mammalian target of rapamycin (mTOR) complex 2 (mTORC2) on natural killer (NK) cell activation by resveratrol. Interferon (IFN)-γ secretion in NK92 cells after the indicated treatments for 48 h determined using an enzyme-linked immunosorbent assay. NK cell cytotoxicity was determined using the calcein-AM assay. NK92 effector cells were harvested after the indicated treatments for 36 h, followed by incubation with K562 target cells at a 1:1 ratio for 4 h. (a) An Akt inhibitor (MK-2206) was added 30 min before resveratrol treatment. (b) An mTOR inhibitor (KU-0063794) was added 30 min before resveratrol treatment. Results are presented as mean ± SD of triplicate measurements. Three independent experiments were performed. Asterisks indicate statistical significance using one-way ANOVA: * p < 0.05, ** p < 0.01, *** p < 0.001, ns: not significant (p > 0.05).