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MRE11, RAD50 and NBS1/NBN form a hexameric complex. (A) Two subunits each of MRE11, RAD50, and NBN assemble in a hexameric complex to form a ring. The coil-coiled domains of RAD50 (red rope like diagrams) facilitates this ring structure. (B) A different structure assumed by the MRN complex to tether the broken chromosome ends together. Adapted from Lafrance-Vanasse et al., 2015.
