Table 1.

MRE11, RAD50 and NBS1/NBN residue conservation.

Gene	Residue Conservation from Alignment Data 1		Statistical Analysis of Mutations from COSMIC (Chi Square) 2
	Residue Type	Number of Residues	Observed	Expected	Chi-Square Value	Chi-Square Sum	p-Value
MRE11	Identity	113	52	43.36	1.72	2.05	0.152206
	Non-conserved	595	219	227.64	0.33
RAD50	Identity	136	81	56.58	10.54	11.76	0.000605
	Non-conserved	1176	463	487.42	1.22
NBN	Identity	38	30	18.45	7.23	7.61	0.005805
	Non-conserved	716	339	350.55	0.38

¹ These data represent the numbers (identical vs. non-conserved) from alignment data (Supplementary Figure S1). ² These data represent the COSMIC point mutations that fall within the conserved or non-conserved residues.