Table 4.
Changes in asthma-related outcomes and immunological parameters as compared to the control group for the weight loss cluster.
| First Author (Year) | Jadad Score * | Intervention and Dose | Asthma-Related Outcomes | Immunological Parameters | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lung Function | Asthma Control | QoL | |||||||||
| FEV1 | FVC | ACT | ACQ | (P)AQLQ | FeNO | Cells (Sputum, Blood) | Th2, IgE | Pro-Inflammatory Markers | |||
| Dias-Junior (2014) [46] | 3 | Low-calorie intake, use of sibutramine (10 mg/day) and use of orlistat (max. 120 mg/day) | = | ↑ | ↑ | ↓ | = | = | = | = | |
| Jensen (2013) [47] | 3 | Energy reduction (−500 kcal/day) and counseling sessions |
= | = | ↓ | = | = | ↓; = | ↓; = | ||
| Toennesen (2018) [48] | 3 | High protein and low glycemic index diet | = | = | = | = | = | = | = | ||
| Combination of diet and exercise | = | = | ↓ | ↑ | = | = | = | ||||
Abbreviations: FEV1 = forced expiratory flow in one second; FVC = forced vital capacity; ACT = asthma control test; ACQ = asthma control questionnaire; (P)AQLQ = (pediatric) asthma quality of life questionnaire; FeNO = fractional exhaled nitric oxide; Th = T helper cell; IgE = immunoglobulin E; QoL = quality of life; ↑ = significant increase as compared to the control group; ↓ = significant decrease as compared to the control group; = = no change as compared to the control group; * = Jadad score was calculated to assess the methodological quality of the RCTs. The calculation of the Jadad score can be found in Supplemental Table S1. Quantitative data showing the within-group changes is presented in Supplemental Tables S3–S7.