Table 6.
Changes in asthma-related outcomes and immunological parameters as compared to the control group for the omega-3 long-chain polyunsaturated fatty acids (LCPUFA) cluster.
| First Author (Year) | Jadad Score * | Intervention and Dose | Asthma-Related Outcomes | Immunological Parameters | ||||
|---|---|---|---|---|---|---|---|---|
| Lung Function | Asthma Control | |||||||
| FEV1 | PEF | ACQ | FeNO | Cells (Sputum, Blood) | Other | |||
| Emelyanov (2002) [54] | 5 | Lipid extract of the New Zealand green-lipped mussel 200 mg/day EPA+DHA |
= | ↑; = | ↓ 1 | |||
| Hodge (1998) [55] | 4 | Omega-3 fatty acid-rich diet and omega-3 fatty acid supplementation 1200 mg/day EPA+DHA |
= | = | ||||
| Mickleborough (2013) [56] | 5 | Marine lipid fraction PCSO-524™ 400 mg/day omega-3 LCPUFA, of which 120 mg/day EPA+DHA |
↑ | ↓ | ||||
| Moreira (2007) [57] | 5 | N-3 PUFA 780 mg/day EPA+DHA 10 mg/day vitamin E |
= | = | = | |||
| Schubert (2009) [58] | 4 | N-3 PUFA-enriched fat blend 750 mg/day (of which 630 mg/day EPA+DHA) |
= | ↓ | = | |||
Abbreviations: FEV1 = forced expiratory flow in one second; PEF = peak expiratory flow; ACQ = asthma control questionnaire; FeNO = fractional exhaled nitric oxide; ↑ = significant increase as compared to the control group; ↓ = significant decrease as compared to the control group; = = no change as compared to the control group; * = Jadad score was calculated to assess the methodological quality of the RCTs. The calculation of the Jadad score can be found in Supplemental Table S1; 1 = exhaled H2O2. Quantitative data showing the within-group changes is presented in Supplemental Tables S3–S7.