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. 2020 Dec 16;21(24):9582. doi: 10.3390/ijms21249582

Table 2.

miRNA-ceRNAs networks identified by transcriptome profiling studies and computational prediction associated with NDDs.

Disease ceRNETs Sample Outcomes Representative Networks Ref.
AD lncRNA-miRNA-mRNA Mouse model (APP/PS1)
brain (cortical samples)
12 months		 One ceRNA network that included 4 lncRNAs, 5 miRNAs and 1082 mRNAs mainly related to AD-associated genes.

  • Rpph1/miR-326-3p, miR-330-5p/Cdc42

  • C030034L19Rik/miR-182-5p/Bdnf

  • Gm15477/miR-484/Flnb

  • A830012C17Rik/miR-132-3p/Smad4

 [43]
Mouse model (APP/PS1)
brain (cortical samples)
6 and 9 months		 3 ceRNA networks built with lncRNAs, miRNAs and mRNAs differentially expressed according to the age at which they are found deregulated (6, 9 or 6 and 9 months).

  • LNC_000854/miR-122-5p/Klf4 (6 months)

  • LNC_000033/miR-128-2-5p, miR.135b-5p, miR.3097-3p, miR-31-5p, miR-449a-5p/Synpo (6 months)

  • LNC_000217/miR-679-5p/Akap5 (9 months)

  • LNC_002639/miR-30B-5P/Fyn (6 and 9 months)

 [96]
Human brain
(neurons from entorhinal cortex of mid-stage AD cases)		 A neurofibrillary tangles-associated ceRNA network was built with 41 lncRNAs, 630 mRNAs and 2530 edges.

  • KB-1460A1.5/miR-302/PTEN

 [97]
Human brain
(prefrontal cortex)		 An AD-associated ceRNET containing 6 lncRNAs, 3 miRNAs and 91 mRNAs.

  • CERS6-AS1/miR-15B-5P/PTEN

  • CTB-89H12.4/miR-155-5p/CASP6

 [98]
circRNA-miRNA-mRNA Mouse model (SAMP8)
brain
7 months		 Two ceRNA networks built with circRNAs, miRNAs and mRNAs found differentially expressed.

  • 6 circRNAs (mm10_circ_0027470, mm10_circ_ 0011311, mm10_circ_0018430, mm10_circ_0009478, mm10_circ_0010326, mmu_circ_0001442)/mmu-let-7g-3p/Hmgb2

  • 5 circRNAs (mmu_circ_0000967, mmu_ circ_0001293, mm10_circ_0027491, mm10_ circ_0027459, mm10_circ_0027483)/miR-122-5p/Dio2

 [99]
Mouse model (Tg2576)
brain
7 and 12 months		 Four ceRNA networks built with circRNAs, miRNAs and mRNAs found differentially expressed.

  • mmu_circ_37345/miR_335-3p/SLY (12 months)

 [100]
Rat model (Aβ1-42)
brain (hippocampal samples)		 A ceRNA network built with 140 circRNAs, 140 miRNAs and 20 mRNAs with 503 relationships.

  • circ_101834 and circ_004690/miR-7a-5p/Aqp3

 [101]
AD circRNA-miRNA-mRNA Mouse model (SAMP8)
brain (hippocampal samples)
5 and 10 months		 A ceRNA network predicted.

  • mmu_circ_017963/5 miRNAs (mmu_miR_1896, mmu_miR_1955-5p, mmu_miR_7030-3p, mmu_ miR_7033-3p, mmu_miR_542-5p)/313 mRNAs

 [102]
Mouse model (SAMP8)
brain (hippocampal)
5 months		 Two ceRNETs built with 2 circRNAs found differentially expressed in PNS-treated mice: mmu_circ_013636, 5 miRNAs and 442 mRNAs, mmu_circ_012180, 5 miRNAs and 631 mRNAs.

  • mmu_circ_012180/miR_6972-5p/Gsdmd

 [103]
Mouse model (APP/PS1) brain (cortex)
6 and 9 months		 Five ceRNA networks were constructed based on differentially expressed circRNAs, miRNAs and mRNAs.

  • 6 circRNAs (mmu_circ_0000452, mmu_circ_0000453, novel_circ_0010838, novel_circ_0011428, novel_circ_ 0033961, novel_circ_0037760)/mmu-miR-466b-5p/Scube2

  • 4 miRNAs (mmu-miR-219b-5p, mmu-miR-350-5p, mmu-miR-450b-5p, mmu-miR-9b-5p)/Sorbs2

  • 7 circRNAs (mmu_circ_0000433, novel_circ_ 0019965, mmu_circ_0001473, novel_circ_0021924, novel_circ_0028455, novel_circ_0051361, novel_ circ_0058143)/mmu-miR-122b-3p/Cntnap2

  • Mmu_circ_0044900/4 miRNAs (mmu-miR-449a-5p, mmu-miR-467a-3p, mmu-miR-540- 3p, and mmu-miR-669f-3p)/Creb

 [104]
Mouse model (5xFAD)
pineal gland
5 months		 A circRNA-miRNA network was constructed with 10 circRNAs. From it, a complete ceRNA net was predicted.

  • circMboat2 and circNlrp5-ps/miR-483/Aanat

 [105]
Human brain An AD-associated ceRNET was constructed with 276 circRNAs, 14 miRNAs and 1117 mRNAs. AD risk ceRNET of KIAA1586 was stablished with 3 miRNAs (hsa-miR-29b, hsa-miR-101 and hsa-miR-15a) and 159 mRNAs.

  • KIAA1586/miR-15a/PSEN2

  • KIAA1586/miR-101/UBE2A

  • KIAA1586/miR-15a, miR-29b/BACE1

 [106]
Human brain A circRNA-mRNA co-expression network was predicted.

  • circHOMER1/miR-651/PSEN1 and PSEN2

  • circCORO1C/miR-105/APP and SNCA

 [107]
AD circRNA-miRNA-mRNA Human brain A circRNA-mRNA co-expression network was predicted

  • hsa_circ_0000994 and hsa_circ_0005232 (from SLC8A1 gene)/-/EPHA4

 [108]
Human cerebrospinal fluid A circRNA-miRNA network was built with the top 5 up- and down-regulated circRNAs (circ-LPAR1, circ-AXL, circ-GPHN, circ-ITPR3, circ-GPI, circ-HAUS4, circ-KIF18B, circ-ATP9A, circ-PCCA and circ-TTC39C).

  • circ-TTC39C/miR-210-3p/BDNF

  • circ-PCCA/miR-138-5p/RARA

 [109]
Human blood (PBMCs) Four nets constructed: (I) circRNA-miRNA network with the top 10 up- and down-regulated circRNAs (II) ceRNA network of hsa_circ_082547 (III) ceRNA network with 3 circRNAs (hsa_circ_101618, hsa_circ_405619, and hsa_circ_000843), 15 miRNAs and 223 mRNAs. (IV) ceRNA network of 4 circRNAs (hsa_circ_402265, hsa_circ_061346, hsa_circ_405836 and hsa_circ_061343), 20 miRNAs and 576 mRNAs.

  • hsa_circ_061346/hsa-miR-5916-3p/APP

  • hsa_circ_000843/hsa-miR-335-3p/SLC8A1

  • hsa_circ_061346/hsa-miR-103a-2-5p/HOMER1

  • 13 circRNAs (hsa_circ_101367, hsa_circ_101368, hsa_circ_103729, hsa_circ_406440, hsa_circ_ 101726, hsa_circ_103394, hsa_circ_100861, hsa_ circ_102448, hsa_circ_103548, hsa_circ_037274, hsa_circ_101159, hsa_circ_104137, hsa_circ_101740)/miR-455-3p/APP

 [110]
PD lncRNA-miRNA-mRNA PD cell model
(SY-SH5Y cells treated with α-synuclein oligomer)		 PD-associated ceRNET that included the lncRNAs AC009365.4, RPS14P3 and G046036 together with the mRNAs IRF1, RIMKA, NAV1, SACS and SDC2. [111]
Human blood A ceRNA regulatory network, including 7 lncRNAs (XIST1, PART1, MCF2L2, NOP14-AS1, LINC00328, LINC00302 and FAM215A), 3 miRNAs (miR-7, miR-433 and miR-133b), and 55 mRNAs.

  • XIST1/miR-7/IGF1R, RKAG2, RAD51 and ITCH

  • XIST1/miR-433/CA12, CTH and PRKACA

  • PART1/miR-133b/IGF1R and CTH

 [112]
Human brain
(substantia nigra)		 A ceRNA network associated with PD, that included 9 lncRNAs, 18 miRNAs, and 185 mRNA.

  • XIST/miR-615-3p/mRNAs

  • NEAT1/miR-124-3p/mRNAs

 [113]
circRNA-miRNA-mRNA Mouse model (MPTP)
brain		 A ceRNET built with 6 circRNAs (circ_0003292, circ_0001320, circ_0005976, circ_0005388, circ_0012384, and circ_003328), 13 miRNAs and 112 mRNAs.

  • mmu_circ_0003292/miR-132/Nr4a2

  • mmu_circ_0001320/miR-124/Sox9

 [114]
Human brain A circRNA-associated ceRNA network predicted and validated.

  • circSLC8A1/miR-128/BMI1, SIRT1 and AXIN1

 [115]
ALS circRNA-miRNA-mRNA Human blood
(leukocytes)		 Two networks predicted.

  • hsa_circ_0023919/miR-9/NEFL

  • hsa_circ_0063411/miR-647/-

 [116,117]