Table 2.
Disease | ceRNETs | Sample | Outcomes | Representative Networks | Ref. |
---|---|---|---|---|---|
AD | lncRNA-miRNA-mRNA | Mouse model (APP/PS1) brain (cortical samples) 12 months |
One ceRNA network that included 4 lncRNAs, 5 miRNAs and 1082 mRNAs mainly related to AD-associated genes. |
|
[43] |
Mouse model (APP/PS1) brain (cortical samples) 6 and 9 months |
3 ceRNA networks built with lncRNAs, miRNAs and mRNAs differentially expressed according to the age at which they are found deregulated (6, 9 or 6 and 9 months). |
|
[96] | ||
Human brain (neurons from entorhinal cortex of mid-stage AD cases) |
A neurofibrillary tangles-associated ceRNA network was built with 41 lncRNAs, 630 mRNAs and 2530 edges. |
|
[97] | ||
Human brain (prefrontal cortex) |
An AD-associated ceRNET containing 6 lncRNAs, 3 miRNAs and 91 mRNAs. |
|
[98] | ||
circRNA-miRNA-mRNA | Mouse model (SAMP8) brain 7 months |
Two ceRNA networks built with circRNAs, miRNAs and mRNAs found differentially expressed. |
|
[99] | |
Mouse model (Tg2576) brain 7 and 12 months |
Four ceRNA networks built with circRNAs, miRNAs and mRNAs found differentially expressed. |
|
[100] | ||
Rat model (Aβ1-42) brain (hippocampal samples) |
A ceRNA network built with 140 circRNAs, 140 miRNAs and 20 mRNAs with 503 relationships. |
|
[101] | ||
AD | circRNA-miRNA-mRNA | Mouse model (SAMP8) brain (hippocampal samples) 5 and 10 months |
A ceRNA network predicted. |
|
[102] |
Mouse model (SAMP8) brain (hippocampal) 5 months |
Two ceRNETs built with 2 circRNAs found differentially expressed in PNS-treated mice: mmu_circ_013636, 5 miRNAs and 442 mRNAs, mmu_circ_012180, 5 miRNAs and 631 mRNAs. |
|
[103] | ||
Mouse model (APP/PS1) brain (cortex) 6 and 9 months |
Five ceRNA networks were constructed based on differentially expressed circRNAs, miRNAs and mRNAs. |
|
[104] | ||
Mouse model (5xFAD) pineal gland 5 months |
A circRNA-miRNA network was constructed with 10 circRNAs. From it, a complete ceRNA net was predicted. |
|
[105] | ||
Human brain | An AD-associated ceRNET was constructed with 276 circRNAs, 14 miRNAs and 1117 mRNAs. AD risk ceRNET of KIAA1586 was stablished with 3 miRNAs (hsa-miR-29b, hsa-miR-101 and hsa-miR-15a) and 159 mRNAs. |
|
[106] | ||
Human brain | A circRNA-mRNA co-expression network was predicted. |
|
[107] | ||
AD | circRNA-miRNA-mRNA | Human brain | A circRNA-mRNA co-expression network was predicted |
|
[108] |
Human cerebrospinal fluid | A circRNA-miRNA network was built with the top 5 up- and down-regulated circRNAs (circ-LPAR1, circ-AXL, circ-GPHN, circ-ITPR3, circ-GPI, circ-HAUS4, circ-KIF18B, circ-ATP9A, circ-PCCA and circ-TTC39C). |
|
[109] | ||
Human blood (PBMCs) | Four nets constructed: (I) circRNA-miRNA network with the top 10 up- and down-regulated circRNAs (II) ceRNA network of hsa_circ_082547 (III) ceRNA network with 3 circRNAs (hsa_circ_101618, hsa_circ_405619, and hsa_circ_000843), 15 miRNAs and 223 mRNAs. (IV) ceRNA network of 4 circRNAs (hsa_circ_402265, hsa_circ_061346, hsa_circ_405836 and hsa_circ_061343), 20 miRNAs and 576 mRNAs. |
|
[110] | ||
PD | lncRNA-miRNA-mRNA | PD cell model (SY-SH5Y cells treated with α-synuclein oligomer) |
PD-associated ceRNET that included the lncRNAs AC009365.4, RPS14P3 and G046036 together with the mRNAs IRF1, RIMKA, NAV1, SACS and SDC2. | [111] | |
Human blood | A ceRNA regulatory network, including 7 lncRNAs (XIST1, PART1, MCF2L2, NOP14-AS1, LINC00328, LINC00302 and FAM215A), 3 miRNAs (miR-7, miR-433 and miR-133b), and 55 mRNAs. |
|
[112] | ||
Human brain (substantia nigra) |
A ceRNA network associated with PD, that included 9 lncRNAs, 18 miRNAs, and 185 mRNA. |
|
[113] | ||
circRNA-miRNA-mRNA | Mouse model (MPTP) brain |
A ceRNET built with 6 circRNAs (circ_0003292, circ_0001320, circ_0005976, circ_0005388, circ_0012384, and circ_003328), 13 miRNAs and 112 mRNAs. |
|
[114] | |
Human brain | A circRNA-associated ceRNA network predicted and validated. |
|
[115] | ||
ALS | circRNA-miRNA-mRNA | Human blood (leukocytes) |
Two networks predicted. |
|
[116,117] |