Table 4.
The top ten metabolites associated with the liver PDFF following adjustment for age, gender, fat mass, and fasting glucose, as well as further adjusted for lipoprotein levels (serum triglycerides, HDL-, and LDL-cholesterol)
| Metabolite | Beta (95% CI) |
P-value Adjusted for Age, Sex, Fat Mass, and Fasting Glucose |
P-value Adjusted for Triglycerides, LDL-, and HDL- Cholesterol |
|---|---|---|---|
| 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)a | 0.47 (0.34, 0.6) | 4.02e-11 | 4.17e-10 |
| behenoyl dihydrosphingomyelin (d18:0/22:0)a | 0.35 (0.22, 0.47) | 1.56e-07 | 2.79e-08 |
| betaine | -0.35 (-0.48, -0.22) | 5.56e-07 | 5.16e-07 |
| 1-palmitoyl-2-oleoyl-GPI (16:0/18:1)a | 0.36 (0.22, 0.5) | 7.31e-07 | 3.24e-06 |
| X—19438 | 0.37 (0.22, 0.52) | 3.67e-06 | 0.0000244 |
| lactate | 0.36 (0.21, 0.5) | 3.80e-06 | 0.0001229 |
| X—24295 | 0.33 (0.19, 0.47) | 4.71e-06 | 0.0001338 |
| 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | 0.32 (0.19, 0.45) | 4.74e-06 | 0.0105331 |
| 1-stearoyl-2-oleoyl-GPE (18:0/18:1) | 0.31 (0.18, 0.45) | 0.0000125 | 0.0204211 |
| 1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4)a | 0.36 (0.2, 0.51) | 0.0000126 | 0.00052 |
Abbreviations: CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PDFF, proton density fat fraction.
a Indicates that there is no available standard.