Table 3.

Distribution of nontruncating^aTMEM127 variants relative to transmembrane domains

Location of nontruncating variants	Amino acids involvedb	No. of nontruncating variants	Nontruncating variants, %	TMEM127 amino acid sequence, %	P, Fisher exact test
TM1	30-53	7	15.2	10.1
TM2	96-116	3	6.5	8.8
TM3	130-150	11	23.9	8.8
TM4	169-190	7	15.2	9.2
No. of amino acids (all TM domains)	88	28	52.8	37.0
No. of amino acids (non-TM domains)	150	18	34.0	63.0
Total nontruncating variants	NA	46			.0117

Abbreviations: NA, not available; TM, transmembrane domain; TMEM127, transmembrane protein 127 gene.

^a Missense or in-frame insertions or deletions.

^b The limits of each transmembrane domain are estimated based on consensus in silico and experimental predictions; precise limits will require crystal structure models, which are currently unavailable for TMEM127.