Table 3.
Correlation of change in serum procollagen type I amino-terminal propeptide with different variables
| Variable | Spearman r | P |
|---|---|---|
| Change in serum T | –0.44 | < .001a |
| Change in serum E2 | –0.15 | .19 |
| Day 28 serum LHb | –0.43 | < .001a |
| Change in weight | 0.33 | .002a |
| Change in Hct | 0.13 | .26 |
| Change in HDL-C | –0.36 | .001a |
| Change in SHBG | –0.36 | .001a |
| Mean trough DMA | –0.16 | .16 |
| Day 28 CMax DMA | –0.02 | .87 |
| Day 28 AUC DMA | –0.02 | .88 |
| Dose of DMAU | 0.40 | < .001a |
Change calculated as difference between first measurement on day 28 and day 1 of treatment.
Abbreviations:; AUC, area under the curve; CMax, maximum serum concentrations; DMA, dimethandrolone; DMAU, dimethandrolone undecanoate; E2, estradiol; Hct, hematocrit; HDL-C, high-density lipoprotein cholesterol; LH, luteinizing hormone; P1NP, procollagen type I amino-terminal propeptide; SHBG, sex-hormone binding globulin; T, testosterone.
a P less than .05 was significant.
b Used pre-dose LH value on day 28 visit.