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. 2020 Dec 16;10(12):1683. doi: 10.3390/biom10121683

Figure 1.

Figure 1

Proposed participation of each glycogen synthase kinase-3 (GSK3) paralog in the synthesis of the Aβ 40/42 peptide. The synthesis of the Aβ 40/42 peptide is the result of amyloid peptide precursor protein (APP) modification that leads to C-99 intermediate peptide formation. It seems that GSK3β regulates the activity of aspartyl protease beta-secretase (BACE1), while GSK3α modulates the activity of the presenilin-dependent γ-secretase (γ-secretase). The Aβ 40/42 peptide stimulates GSK3α to phosphorylate tau protein.