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Specific inhibition of GSK3 may be beneficial in acute myeloid leukemia. Left panel: The selective inhibitors BRD-0705, Tivantinib, and others reported by Neuman et al. [89] promote the differentiation of acute myeloid leukemia (AML) cells without the stabilization of β-catenin and without deleterious effects [29,43,90,91]. Right panel: The inhibition of both GSK3 paralogs leads to deleterious effects and promotes β-catenin stabilization and cell proliferation [29,85].
