Table 2.

Biological effects of GSK3 and GSK3 inhibition by selected compounds.

Molecule	GSK3α Inhibition, IC50 (nM)	GSK3β Inhibition, IC50 (nM)	Reported Biological Effect	References
BRD0705	66	515	Induces cell differentiation of AML cell lines and impairs colony formation of AML patient cells	[29]
EHT5372	7.44	221	Reduces phosphorylation of tau and Aβ production on recombinant expressing HEK293 cells	[97]
AZD2858	0.9	5	Reduces tau hyperphosphorylation in rat brains, and induces differentiation of mesenchymal progenitors to osteoblasts	[112] [113]
EHT1610	9.11	143	Reduces phosphorylation of tau and Aβ production on recombinant expressing HEK293 cells	[97]
8g	35	966	Unknown	[111]
8a	4	90	Unknown	[111]
8b	9	225	Unknown	[111]
27	42	140	Induces differentiation and impairs colony formation of AML, HL-60, and NB4 cells	[89]
26d	2	17	Unknown	[89]
14a	9	176	Unknown	[104]
15b	2	185	Unknown	[104]
14d	6	316	Unknown	[104]
G28_14	33	218	Induces differentiation and impairs colony formation of AML, HL-60, and NB4 cells	[114]
Λ-OS1	0.9	6	Unknown	[96]
Tivantinib	659	1865	Apoptosis of AML cells	[91]