Figure 8.
Muscle weight loss and muscle fiber cross-sectional area (CSA) loss in supraspinatus in wild-type mice that underwent sham and TT + DN surgery combined with treatment after a 6-week (w) delay. All groups that underwent TT + DN surgery combined with 5% dimethyl sulfoxide (DMSO) and 10-mg/kg amibegron after a 6-week delay had significant muscle weight loss and CSA loss when compared with the group that underwent sham surgery combined with 5% DMSO after a 6-week delay. However, the group that underwent TT + DN surgery combined with 10-mg/kg amibegron after a 6-week delay had improved muscle weight loss and CSA loss when compared with the group that underwent TT + DN surgery combined with 5% DMSO after a 6-week delay. Solid lines indicate P < .05, and dashed linesf indicate P < .01. Error bars indicate standard deviations.