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. 2020 Dec 22;13:1613–1620. doi: 10.2147/IJGM.S286421

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© 2020 Chen et al.

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Clinical spectrum of CSF1R-related leukoencephalopathy. (A) Typical brain lesions of CSF1R-related leukoencephalopathy. White matter lesions were the most common lesions, which mainly located in the periventricular areas, frontal lobes, corpus callosum and parietal lobes. Atrophy and thinning of the corpus callosum were also noted. (B) Initial symptoms of CSF1R-related leukoencephalopathy. Cognitive impairment, parkinsonism, abnormal behaviors and mental disorders are the most common initial symptoms. (C) Typical manifestations of CSF1R-related leukoencephalopathy during the disease course. Cognitive impairment, parkinsonism, gait disorder, personal and behavioral abnormalities, and dysarthria are the most common typical manifestations during the disease course.