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Schematic diagram for the chemical structure of baicalein and 7,8-DHF and the interacting residues of ODC. (A) Hydrogen bonding of the hydroxyl moieties at C-5 and C-6 on the A ring and the oxygen atom on the C ring of baicalein with Ser200, Arg277, Asp332, and Gly362 in the dimer interface of ODC. (B) Hydrogen bonding of the hydroxyl moieties at C-7 and C-8 on the A ring and the oxygen atom at C-4 on the C ring of 7,8-DHF with Ser200, Gly201, and Gly362 in the dimer interface of ODC.
