Table 1.
Flavonoids with A ring substitution(s) and with the the half maximal inhibitory concentration (IC50) to ornithine decarboxylase (ODC).
| Compound | IC50 | Chemical Structure | Characteristics |
|---|---|---|---|
| Flavone | No inhibition |
|
No A ring substitution |
| Baicalein (5,6,7-trihydroxyflavone) |
0.88 μM |
|
A ring substitution: 5,6,7-tri-OH |
| 7,8-Dihydroxyflavone (7,8-DHF) |
2.54 μM |
|
A ring substitution: 7,8-di-OH |
| 6,7-Dihydroxyflavone (6,7-DHF) |
289 μM |
|
A ring substitution: 6,7-di-OH |
| Chrysin | No inhibition |
|
A ring substitution: 5,7-di-OH |
| 7,8-Dimethoxyflavone | No inhibition |
|
A ring substitution: 7,8-di-OCH3 |
| Pinocembrin | No inhibition |
|
A ring substitution: 5,7-di-OH |
| 6-Hydroxyflavone | No inhibition |
|
A ring substitution: 6-OH |
| 7-Hydroxyflavone | No inhibition |
|
A ring substitution: 7-OH |