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. 2020 Dec 17;6(4):373. doi: 10.3390/jof6040373

Figure 3.

Figure 3

PK:PD relationship for PC945 in Aspergillus-infected, temporarily neutropenic mice. PC945 (0.56 µg/mouse) was administered once daily intranasally from day 7 to day 0 or from day 1 to day 0 before A. fumigatus inoculation, and BAL was collected 24 h or 72 h after the last dose and A. fumigatus inoculation. BAL cells and BAL supernatant were separated by centrifugation. The levels of PC945 in BAL cell extracts are shown in panel (A). (B) Non-infected intact mice were given PC945 (0.56 µg/mouse) once daily for 7 days or for 2 days, or PC945 (14 µg/mouse) for 3 days, and PC945 concentration in BAL cell extracts was measured at 6, 24, 48, 72 and/or 240 h post the last dose. (C) The relationship between PC945 in BAL cell extracts and inhibition of galactomannan (GM) in BAL in Aspergillus-infected, temporarily neutropenic mice (E). Each horizontal bar is presented as mean ± SD. 5 mice per group. * p < 0.05, **** p < 0.0001 by ANOVA-unpaired t-test with Welch’s correction. V: vehicle. Adapted from [48].