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Summary of studies undertaken which support the investigation of PC945 in clinical studies.
| Binding assays in vitro to assess potential for off-target interactions In vitro and in vivo genotoxicology Safety pharmacology (cardiovascular and behavioural) Oral bioavailability and interaction with CYP enzymes 14 day- and 13 week-repeat dose safety assessment (inhaled dosing) in rats and dogs Reproductive toxicology Phototoxicology |
