Table A2.
Baseline characteristics of patients with pre-existing diabetes vs. GC-induced diabetes.
| All Patients with Hyperglycemia (n = 812) | GC-Induced Diabetes (n = 399) | Pre-Existing Diabetes and Hyperglycemia (n = 413) | p-Value | |
|---|---|---|---|---|
| Male sex, n (%) | 356 (44%) | 188 (47%) | 168 (40.7%) | 0.066 |
| Age, y, mean (interquartile range) | 68.5 (±13.4) | 65.92 (±15.71) | 71.03 (±10.14) | <0.001 |
| Clinical variables | ||||
| Body mass index kg/m2 (IQR) | 26.6 (23.4–31) | 25.3 (22–29) | 28 (24.78–32.6) | <0.001 |
| Mean glucocorticoid (GC) dose 1 mg/kg/day | 1.22 (±3.3) | 1.79 (±4.1) | 0.66 (±2.2) | <0.001 |
| Duration of GC administration (in days) | 5.12 (±2.1) | 5.33 (±2.1) | 4.92 (±2.2) | 0.006 |
| Length of stay | 9.0 (6.0–15.0) | 9.0 (5.0–15) | 9.0 (6.0–15.0) | 0.43 |
| Charlson Comorbidity Index | 2.0 (1.0–3.0) | 2.0 (1.0–3.0) | 2.0 (1.0–3.0) | 0.049 |
| Indication for GC administration | 0.01 | |||
| Autoimmune-inflammatory | 300 (36.9%) | 156 (39.1%) | 144 (34.9%) | |
| Oncology | 175 (21.6%) | 99 (24.8%) | 76 (18.4%) | |
| Pneumology/Infectiology | 294 (36.2%) | 123 (30.8%) | 171 (41.4%) | |
| Endocrinology/others | 43 (5.3%) | 21 (5.3%) | 22 (5.3%) | |
| Diabetes-related parameters | ||||
| Glucose on admission | 8.2 (6.55–10.6) mmol/L/ 148 (118–191) mg/dL |
7.1 (5.9–8.8) mmol/L/ 128 (106–159) mg/dL |
9.52 (7.7–12.8) mmol/L/ 172 (139–231) mg/dL |
<0.001 |
| Mean glucose differences from peaks to nadirs (MAGE) | 4.89 (±2.18) | 4.12 (±1.87) | 5.63 (±2.21) | <0.001 |
| Glucose (coefficient of variation) 2 | 0.3 (±0.1) | 0.27 (±0.09) | 0.32 (±0.09) | <0.001 |
| Insulin pre-treatment (including type 1 and pancreatogenic) | 173 (21.3%) | 173 (21.3%) | ||
| Pre-treatment with glucose-lowering agents other than insulin | 178 (21.9%) | 178 (43%) | ||
| Diabetes treatment with dietary measures | 62 (7.64%) | 62 (15%) |
Data is shown as n (%) or mean/median (standard deviation or interquartile range) per group. GC: glucocorticoid. 1 mean GC dose is given as normalized GC dose in mg per prednisolone equivalent per kg per day. 2 CV = SD/mean ∗ 100%.