AAV |
adeno-associated virus |
AMD |
age-related macular degeneration |
AP |
alternative pathway |
ARM |
age-related maculopathy |
BRB |
blood-retina barrier |
C3 |
complement component 3 (same for C2, C4, etc.) |
C3(H2O)Bb |
fluid-phase C3-convertase |
CC |
choriocapillaris |
CNV |
choroidal neovascularization |
CP |
classical pathway |
CR1 |
complement receptor 1 |
dAMD |
dry AMD |
EMA |
European Medicines Agency |
ECM |
extracellular matrix |
FDA |
Food and Drug Administration |
FB |
factor B |
FD |
factor D |
FH |
factor H |
FI |
factor I |
GA |
geographic atrophy |
GAG |
glycosaminoglycans |
GWAS |
genome-wide association study |
Ig |
immunoglobulin |
KO |
knock-out |
LP |
lectin pathway |
MAC |
membrane-attack complex |
MASP |
MBL-associated serine protease |
MBL |
mannose-binding lectin |
mRNA |
messenger RNA |
PEDF |
pigment endothelial-derived factor |
PR |
photoreceptor |
rCD59 |
recombinant CD59 |
RPE |
retinal pigment epithelium |
SNP |
single nucleotide polymorphism |
TNF-α |
tumor necrosis factor-alpha |
VEGF |
vascular endothelial growth factor |
wAMD |
wet AMD |