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. 2020 Dec 21;21(24):9752. doi: 10.3390/ijms21249752
AAV adeno-associated virus
AMD age-related macular degeneration
AP alternative pathway
ARM age-related maculopathy
BRB blood-retina barrier
C3 complement component 3 (same for C2, C4, etc.)
C3(H2O)Bb fluid-phase C3-convertase
CC choriocapillaris
CNV choroidal neovascularization
CP classical pathway
CR1 complement receptor 1
dAMD dry AMD
EMA European Medicines Agency
ECM extracellular matrix
FDA Food and Drug Administration
FB factor B
FD factor D
FH factor H
FI factor I
GA geographic atrophy
GAG glycosaminoglycans
GWAS genome-wide association study
Ig immunoglobulin
KO knock-out
LP lectin pathway
MAC membrane-attack complex
MASP MBL-associated serine protease
MBL mannose-binding lectin
mRNA messenger RNA
PEDF pigment endothelial-derived factor
PR photoreceptor
rCD59 recombinant CD59
RPE retinal pigment epithelium
SNP single nucleotide polymorphism
TNF-α tumor necrosis factor-alpha
VEGF vascular endothelial growth factor
wAMD wet AMD