Figure 1.

Influence of high fat diet on Aβ and IGF-I levels. (A) Overweight mice show significantly increased fluorescence in the liver and reduced in serum, suggesting increased uptake of fluorescently labeled Aβ_1-40 by the liver and increased clearance from serum (n = 4 per group). (B) Serum levels of IGF-I are increased after 10 weeks of a high-fat diet (n = 10 per group). (C) Brain Aβ_1-40 levels remain unaltered in overweight mice as compared to lean controls (n = 6–8). * p < 0.05 and *** p < 0.001. (D) Brain levels of IGF-I were normal in high fat diet (HFD)-fed overweight mice (n = 10 per group).