Figure 2.

Modulation by IGF-I of Aβ uptake by hepatocytes. (A) IGF-I induces uptake of Aβ by hepatocytes (n = 6). Representative micrograph of cultured hepatocytes with internalized fluorescent Aβ (green). Cell nuclei stained with Hoescht. Lower histograms: Quantification of intracellular fluorescent Aβ after IGF-I treatment. (B) Serum IGF-I deficient mice (liver IGF-I deficient (LID) mice) show reduced Aβ uptake by the liver, which was ameliorated by systemic IGF-I treatment (n = 5 control/6 LID/5 LID + IGF-I). (C) Brain Aβ levels did not change in LID mice (n = 8). * p < 0.05 and *** p < 0.001.