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Reduced entrance of serum IGF-I in overweight mice. (A) In response to environmental enrichment (EE), overweight mice show lower brain IGF-IR phosphorylation than lean mice receiving a standard diet (n = 10 EE/6 Control, for each diet). (B) Interaction of APP with IGF-IR in the brain of mice submitted to EE stimulation was significantly decreased in overweight mice (n = 10 per group). Representative blots are shown, together with quantification histograms. * p < 0.05.
