Aβ	amyloid β
AD	Alzheimer disease
APP	amyloid precursor protein
BBB	blood-brain-barrier
EE	environmental enrichment
FBS	fetal bovine serum
GTT	glucose tolerance test
HFD	high fat diet
IGF-I	insulin-like growth factor I
IGF-IR	IGF-I receptor
KPI	Kunitz protease inhibitor
LID	liver IGF-I deficient
LRP1	lipoprotein receptor related protein 1
NHS	normal horse serum
PB	phosphate buffer
PBS	phosphate buffer saline
PLA	proximity ligation assay