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. 2020 Dec 19;25(24):6029. doi: 10.3390/molecules25246029

Figure 4.

Figure 4

[123I]KX1 induces apoptosis in viable human tumor slices. Tumors from donors with high-grade serous ovarian cancer were viably sectioned using a compresstome. Tumor slices were cultured with 1.85 or 3.7 MBq/mL of [125I]KX1 with or without 500 nM veliparib for 2 h. (A) Tumors were formalin fixed and processed for immunohistochemistry. Serial sections were stained for PARP, cleaved-PARP or HE. (B) Quantification of positive cleaved-PARP staining pixels normalized to the area of tumor. (C) Immunofluorescence of tissue slices treated with 3.7 MBq/mL of [125I]KX1 for 1 h and assessed for DNA damage.