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. 2020 Dec 20;12(12):3055. doi: 10.3390/polym12123055

Table 3.

Literature summary of BBB penetrating nanoparticles (NPs) to mediate the brain tumor therapeutics.

S. No. Nanoplatforms (NF) Target Ligand Therapeutic Features Ref.
1 Fe3O4 NPs Lactoferrin Imaging [51]
2 Polymersome G23 peptide Drug Carrier [52]
3 RGD-QDs RGD peptide NI Imaging [79]
4 EGFpep-Au NPs EGF peptide PDT [80]
5 G4-DOX-PEG-Tf-TAM Transferrin (Tf) Drug delivery [81]
6 ANG-PEG-NP Angiopep-2 Drug delivery [46]
7 PBCA NPs Polysorbate 80 Delivery [82]
8 DTX-ANG20/TAT10-Ms Angiopep-2 Imaging, drug delivery [83]
9 ANG-IMNPs angiopep-2 PTT/PDT [84]
10 Tw-Mtx-Tf-NP Transferrin Drug delivery [67]
11 AP-PLGA-NPs Polysorbate Drug delivery [85]
12 TAT-Au NP TAT peptide Drug delivery, MR imaging [54]
13 DOX-EDT-IONPs Passive Chemotherapy [86]
14 (ICG)-loaded polymeric NPs Passive Imaging, PTT [74]
15 131I-Au PENPs-CTX Chlorotoxin Imaging, Radio therapy [87]
16 MoS2–ICG NSs Passive PA Imaging [88]
17 mPEG-PLGA NPs Passive Dual drug delivery [89]
18 LP-iDOPE Passive NIR imaging, Photo-immune therapy [90]
19 Fe3O4 NPs G23 peptide, passive MR Imaging, drug delivery [91,92]
20 B16-PCL-ICG NPs Cell membrane Fluorescence imaging, PTT [74]
21 BLIPO-ICG NPs Cell membrane Fluorescence imaging, PTT [93]

Abbreviations: arginine-glycine-aspartate (RGD), Quantum dots (QDs), epidermal growth factor peptide (EGFpep), Doxorubicin (DOX), Polyethylene glycol (PEG), Tamoxifen (TAM), Angiopep (ANG), poly(n-butylcyanoacrylate) NPs (PBCA NPs), docetaxel (DTX), transactivator of transcription (TAT), methotrexate (MTX), Acetylpuerarin (AP), poly(lactic-co-glycolic acid) (PLGA), trimethoxysilylpropyl-ethylenediamine triacetic acid (EDT), iron oxide nanoparticles (IONPs), Indocyanine green (ICG), chlorotoxin (CTX), polyethylenimine NPs (PENPs), Molybdenum sulfide (MOS2), liposomally formulated phospholipid-conjugated indocyanine green (LP-iDOPE), poly(ε-caprolactone)(PCL), liposome (BLIPO).