Skip to main content
. 2020 Dec 21;21(24):9742. doi: 10.3390/ijms21249742

Table 1.

lncRNAs and their mechanisms and biological roles in Cervical cancer (CC).

LncRNA Localization Expression Level Signaling Pathways and Molecules Biological Roles Ref.
HOTAIR 12q13.13 Upregulated Notch/Wnt pathway, sponge for miR-143-3p, miR-23b and miR-17-5p. MAPK1, BCL-2, mTOR/p70S6K pathway. Cell growth, cell proliferation and cell survival, EMT metastasis, and invasion [15,16,17,18,19,20]
H19 11p15.5 Upregulated Sponge for let-7 family, miR-106, miR-194, miR-138-5p, miR-675, miR-140, miR-200 and MILK Cell migration, cell proliferation [21,22,23,24,25,26,27]
MALAT1 11q13 Upregulated P16INK4A/CDKs/RB pathway, sponge for miR-145. Cell migration, cell proliferation, vascular invasion, EMT, metastasis. [28,29,30,31,32,33,34]
CCHE1 10q21.1 Upregulated ERK/MAPK pathway. PCNA. Cell proliferation, metastasis. [35,36,37,38]
ANRIL 9p21 Upregulated PI3K/Akt pathway, Sponge for miR-186. Cell proliferation, metastasis [39,40,41,42,43]
CCAT2 8q24.21 Upregulated Cell cycle Cell proliferation, metastasis. [44,45,46]
MEG3 14q32.3 Downregulated Sponge for miR-21-5p. PI3K/AKT/BCL-2/Bax/P21 pathway, PI3K/AKT/MMP-2/9 pathway, P-STAT3. Metastasis, apoptosis. [47,48,49,50]
BLACAT1 1q32.1 Upregulated Wnt/β-catenin pathway, sponge for miR-143 and miR-424. Cell proliferation, cell migration. [51,52,53,54,55,56]
XIST Xq13.2 Upregulated Wnt/β-catenin pathway, sponge for miR-140-5p. Cell proliferation, cell invasion, cell EMT, migration. [36,57,58,59]
SPRY4-IT1 5q31.3 Upregulated sponge for miR-101-3p. ZEB1. Cell proliferation, cell migration [60,61,62,63]
GAS5 1q25.1 Downregulated Sponge for miR-196a and miR-205. Cell proliferation, cell invasion, apoptosis, [64,65,66,67]
DLX6-AS1 7q21.3 Upregulated Sponge for miR-16-5p and miR-199a. ARPP19, FUS. Cell proliferation, cell invasion. [68,69,70,71,72]
HOXD-AS1 2q31.1 Upregulated Ras/ERK pathway, sponge for miR-130a-3p. ZEB1. Cell growth, cell migration, cell invasion. [73,74,75,76]
CRNDE 16q12.2 Upregulated PI3K/AKT pathway, sponge for miR-183. CCNB1, PUMA, P53. Cell proliferation, apoptosis. [77,78,79]
PVT1 8q24.21 Upregulated Smad3, sponge for miR-140-5p, miR-424, miR-195 and miR-200b. EZH2, TGF-β1. Cell growth, cell proliferation, metastasis. [80,81,82,83,84,85]