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(A) Schematic representation of the mesoporous silica nanoparticles (MSNs). MSNs were functionalized with PEI for siRNA loading and further modified with a phosphorylcholine derivative to introduce zwitterionic groups to endow the MSNs with antifouling features. (B) Cytotoxic effect of the functionalized MSNs. The highest cytotoxicity was observed for the groups containing the siRNA and the drug daunorubicin. Reproduced from Ref. [67] with permission from Elsevier.
