Table 3.

Population doubling time (PDT) of SCLC cells. Values are mean ± sd after 14 days of treatment with indicated I-BET762 and/or Talazoparib concentrations. Values are mean ± sd for twelve replicates per treatment.

Cell line	Concentration of I-BET762	Population Doubling Time (h)
		I-BET762	Talazoparib 5 nM + I-BET762
H69	-	52.2 ± 2.3	55 ± 2.8
	0.156 µM	52.2 ± 1.4	57.4 ± 2.9
	0.312 µM	53.7 ± 1.1	58.7 ± 1.3
	0.625 µM	55.2 ± 2	64.2 ± 1.9
	1.25 µM	58.5 ± 1.7	76.1 ± 2.1
	2.5 µM	65.7 ± 2.4	87.6 ± 3.4
	5 µM	76.8 ± 2.7	112.6 ± 5.2
Lu135	-	80 ± 4.9	119.5 ± 10.7
	0.156 µM	83 ± 4.8	163.1 ± 28.6
	0.312 µM	84.5 ± 4.8	186.9 ± 29.7
	0.625 µM	94.4 ± 6.7	202.3 ± 14.7
	1.25 µM	110.4 ± 6.6	236.7 ± 16.6
	2.5 µM	122.1 ± 9.9	287.6 ± 46.3
	5 µM	172.2 ± 27.8	344.1 ± 42.7
N417	-	77.3 ± 5.1	113.5 ± 24.2
	0.156 µM	86.5 ± 7	128.2 ± 15.1
	0.312 µM	93.7 ± 5.5	150.2 ± 32.7
	0.625 µM	103.8 ± 5.8	179.5 ± 26
	1.25 µM	137 ± 13.2	259.7 ± 45
	2.5 µM	161.4 ± 11.7	262.4 ± 111.8
	5 µM	218 ± 35	262.9 ± 101.3