Table 1.

The impact of compounds 10b and 13b on gastric mucosa. Morphine and indomethacin were used as reference drugs. Experimental groups (n = 12): C—control group; M—group receiving 10 mg/kg of morphine; I—group receiving 10 mg/kg of indomethacin; 10b-5, 10b-10, 10b-20—groups receiving, respectively, 5, 10, or 20 mg/kg of investigated compound 10b; 13b-5, 13b-10, 13b-20—groups receiving, respectively, 5, 10, or 20 mg/kg of investigated compound 13b. Scoring scale of macroscopic evaluation of gastric mucosa: (0) = no damage; (1) = 1–4 small petechiae; (2) = 5 or more petechiae or hemorrhagic streaks up to 4 mm; (3) = erosions longer than 5 mm or confluent hemorrhages. Scoring scale of microscopic evaluation of gastric mucosa: (0) = no damage; (1) = mild changes; (2) = moderate changes; (3) = severe changes. Data are presented as mean values ± SEM. Differences ^^^ p < 0.001 vs. the control group; *** p < 0.001 vs. the indomethacin group were deemed statistically significant.

Group	Macroscopic Lesions (0–3 Points)	Microscopic Lesions, H&E Staining (0–3 Points)
control	0	0
M	0	0.43 ± 0.21
I	2.00 ± 0.31 ^^^	2.43 ± 0.30 ^^^
10b-5	0	0
10b-10	0	0.29 ± 0.18
10b-20	0.57 ± 0.20 ***	0.71 ± 0.29 ***
13b-5	0	0
13b-10	0	0
13b-20	0.29 ± 0.18 ***	0.57 ± 0.20 ***