Table 2.

Comparison of the two most common types of CVSD with clinical and neuroimaging characteristics. CVSD—cerebral small vessel disease, CMBs—cerebral microbleeds.

Classification	Type I	Type II
Characteristic	Associated with arteriosclerosis Related age differences Not associated with amyloid deposition Degenerative microangiopathy	Associated with amyloid deposition Rated age differences
Etiology	Atrophy of smooth muscles in tunica media Aggregate of fibro-hyaline material Stenosis of vessel lumen Degeneration of vessel wall Changing of arterial vessels systems	Vasculopathy Aggregate of amyloid in cortical walls or leptomeningeal small arteries but not capillaries Apolipoprotein gene polymorphism
Manifestations	Lacunar strokes in deep part of brain Dementia and cognitive impairment	Intracerebral hemorrhage in cerebral lobes Non-lacunar strokes Hallmarks of Alzheimer’s disease Cognitive impairment, dementia and transient focal neurological episodes
Radiographic features	CMBs in deep part of the brain Rare changes to the siderosis type of the superficial cortical area Presence of basal ganglia perivascular spaces Hyperintensities in the cerebral region of white matter	CMB sin cerebral lobes Cortical superficial siderosis Centrum seniovate perivascular space Posterior dominance with white matter hyperintensities