Table 3.
Overview of PRC-funded research projects (2017–now) covering the parenteral use of liposomal formulations.
| Principal Investigator |
Host | Start/ Status |
Title of Project |
|---|---|---|---|
| Stimuli-Responsive Liposomes | |||
| Robbert Jan Kok | University Utrecht, the Netherlands |
2017, finished |
Encapsulation of plant-derived toxins in stimuli-sensitive liposomes |
| Tatu Lajunen | University of Helsinki, Finland |
2019, ongoing |
Light activated liposomes for cancer therapy |
| Mans Broekgaarden |
University Grenoble, France | 2020, ongoing |
Radiation-responsive liposomes for controlled release and tumor permeation of radiotherapy dose enhancers |
| Heijan Xiong | University of Texas at Dallas, USA | 2020, ongoing |
Highly photosensitive phospholipid nanovesicles for near infrared light-triggered local anesthesia |
| Targeted Liposomes | |||
| Luisa Corvo | University Lisbon, Portugal |
2017, finished |
Targeted liposomal antioxidant and anti- inflammatory therapy for liver ischemic reperfusion injury |
| Jai Prakash | University Twente, the Netherlands |
2018, finished |
Modulating tumor-associated macrophages using cell-specific targeted liposomes |
| Avi Schroeder | Israel Institute of Technology |
2018, ongoing |
Phospholipids as metastases-targeting molecules using barcoding as a new research tool in liposome discovery |
| Michele Bernasconi |
Bern University Hospital, Switzerland | 2020, ongoing |
Targeted liposomal drug delivery to pediatric sarcomas: beyond the EPR effect |
| Joke den Haan | Amsterdam UMC, the Netherlands |
2020, ongoing |
Virus-like liposomes targeting CD169+ dendritic cells as a novel carrier for cancer immunotherapy |
| Ulrike Müller | University Heidelberg, Germany | 2020, ongoing |
Liposome mediated delivery of biologicals to the brain as a novel therapeutic strategy for Alzheimer’s disease |
| Exosomes | |||
| Paola Luciani, Gregor Fuhrmann | University Bern, Switzerland and HIPS, Germany |
2017, ongoing |
Lipid-based therapeutics for liver fibrosis and their impact on extracellular vesicles |
| Raymond Schiffelers | University Medical Center Utrecht, the Netherlands |
2018, ongoing |
Liposome–extracellular vesicle hybrids for therapeutic RNA delivery |
| Jean-Christophe Leroux | ETH Zurich, Switzerland |
2018, ongoing |
Research on the drug loading of exosomes |
| Other Liposomal Approaches | |||
| Federico Bordi, Simona Sennato |
La Sapienza University and CNR-ISC Rome, Italy | 2017, ongoing |
Antitubercular drug-loaded multi-liposomes vectors |
| Hermann Nirschl | KIT, Germany | 2019, ongoing |
Encapsulation of active pharmaceutical ingredients into liposomes via centrifugation of water-in-oil nano-emulsions |
| Ruchi Bansal | University Twente, the Netherlands |
2019, ongoing |
Bioactive liposomes for the treatment of non-alcoholic steatohepatitis (NASH) |
| Enrico Mastrobattista |
University Utrecht, the Netherlands |
2020, ongoing |
Liposome-based coatings for immune stimulation and bone regeneration |