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. 2020 Dec 20;12(12):3847. doi: 10.3390/cancers12123847

Figure 1.

Figure 1

Elevation of Hippo gene expression in osteosarcoma (OS) patients—correlation between YAP expression and overall survival of OS patients. (A) Heatmap showing color-coded expression of Hippo target genes in OS tissue and matched normal tissue from the same OS patient following bioinformatics analysis of RNAseq data GSE99671 [26] from a cohort of 15 OS patients. High expression (red), low expression (blue). (B) GSEA showing a Hippo signature in OS samples following bioinformatics analysis of RNAseq data GSE99671 [26] from an OS patient’s cohort comprising 15 samples. FDR false discovery rate, NES normalized enrichment score. (C) Relative YAP gene expression in OS samples and matched normal tissues of the same patient following bioinformatics analysis of RNAseq data GSE99671 [26] (* p < 0.05). (D) Kaplan–Meier analysis of the survival outcome of patients dichotomized into high and low YAP levels, following analysis of the RNAseq dataset GSE42352 [27] from an OS patient cohort comprising 88 samples. Analysis was performed using R2 (http://r2.amc.nl); p-value is from log-rank tests.